2008•AIDSRequires access

Is there a role for etravirine in patients with Nonnucleoside reverse transcriptase inhibitor resistance?

C Scott, Donald A. Grover, Mark Richard Nelson

Abstract

Etravirine is a next generation nonnucleoside reverse transcriptase inhibitor with activity against nonnucleoside reverse transcriptase inhibitor resistant HIV-1 virus. Susceptibility and virological response to etravirine is dependent on the type and number of nonnucleoside reverse transcriptase inhibitor resistance-associated mutations. We examined the predicted susceptibility of etravirine in patients experiencing virological failure secondary to nonnucleoside reverse transcriptase inhibitor resistance in our patient cohort.

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Key concepts: Etravirine, Reverse-transcriptase inhibitor, Reverse transcriptase, Virology, Biology, Human immunodeficiency virus (HIV), Viral disease, Sida