1961•Journal of Pharmacy and PharmacologyRequires access

The Effect of Cortisone and Hydrocortisone on the Plasma Levels of Corticotrophin in the Rat, After an Acute Stress

A. M. Barrett

Abstract

Abstract Pretreatment of intact female rats with cortisone and hydrocortisone acetates produces a graded inhibition of ACTH release in response to acute stress as shown by changes in plasma ACTH levels. The inhibition was greater with hydrocortisone and was dependent upon the time and dose relations.

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Key concepts: Cortisone, Hydrocortisone, Endocrinology, Internal medicine, Adrenocorticotropic hormone, Medicine, Corticosteroid, Adrenal cortex hormones