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Suppressive Effect of Polysaccharides from the Edible and Medicinal Mushrooms,Lentinus edodesandAgaricus blazei, on the Expression of Cytochrome P450s in Mice

Takashi Hashimoto, Yuji Nonaka, Ken‐ichiro Minato, Sachiko Kawakami, Masashi Mizuno, Itsuko Fukuda, Kazuki Kanazawa, Hitoshi Ashida

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Abstract

To investigate the effects of lentinan from Lentinas edodes and polysaccharides from Agaricus blazei (ABPS) on the expression of cytochrome P450s (CYPs), lentinan (10 mg/kg/day) or ABPS (200 mg/kg/day) was administered to female BALB/c mice four times every other day by intraperitoneal injection. Lentinan and ABPS suppressed both the constitutive and 3-methylcholanthrene-induced CYP1A expression and ethoxyresorufin-O-deethylation activity in the liver.

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What this paper is about

To investigate the effects of lentinan from Lentinas edodes and polysaccharides from Agaricus blazei (ABPS) on the expression of cytochrome P450s (CYPs), lentinan (10 mg/kg/day) or ABPS (200 mg/kg/day) was administered to female BALB/c mice four times every other day by intraperitoneal injection. Lentinan and ABPS suppressed both the constitutive and 3-methylcholanthrene-induced CYP1A expression and ethoxyresorufin-O-deethylation activity in the liver.

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Available abstract

To investigate the effects of lentinan from Lentinas edodes and polysaccharides from Agaricus blazei (ABPS) on the expression of cytochrome P450s (CYPs), lentinan (10 mg/kg/day) or ABPS (200 mg/kg/day) was administered to female BALB/c mice four times every other day by intraperitoneal injection. Lentinan and ABPS suppressed both the constitutive and 3-methylcholanthrene-induced CYP1A expression and ethoxyresorufin-O-deethylation activity in the liver.

Key concepts: Lentinan, Lentinus, Polysaccharide, Mushroom, Agaricus, Chemistry, Cytochrome, Food science

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Suppressive Effect of Polysaccharides from the Edible and Medicinal Mushrooms,Lentinus edodesandAgaricus blazei, on the Expression of Cytochrome P450s in Mice — Research Paper | ScholarLens