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JAK/STAT-Dependent Gene Regulation by Cytokines

Daniel Hebenstreit, Jutta Horejs‐Hoeck, Albert Duschl

Open publisher page 114 citations

Abstract

The Janus kinase-signal transducer and activator of transcription (Jak-STAT) pathway is essential for the signal transduction of many cytokines. Dysregulation of Jak-STAT signaling is associated with various human diseases. Recent studies have helped to shed some light on regulatory mechanisms that modify quantity and quality of the signaling response. Here, we summarize our current knowledge on Jak-STAT signaling.

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What this paper is about

The Janus kinase-signal transducer and activator of transcription (Jak-STAT) pathway is essential for the signal transduction of many cytokines. Dysregulation of Jak-STAT signaling is associated with various human diseases. Recent studies have helped to shed some light on regulatory mechanisms that modify quantity and quality of the signaling response. Here, we summarize our current knowledge on Jak-STAT signaling.

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OpenAlex reports 114 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The Janus kinase-signal transducer and activator of transcription (Jak-STAT) pathway is essential for the signal transduction of many cytokines. Dysregulation of Jak-STAT signaling is associated with various human diseases. Recent studies have helped to shed some light on regulatory mechanisms that modify quantity and quality of the signaling response. Here, we summarize our current knowledge on Jak-STAT signaling.

Key concepts: Janus kinase, stat, STAT protein, JAK-STAT signaling pathway, Signal transduction, STAT3, Activator (genetics), Cell biology

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