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2014•Zhongguo shengwu huaxue yu fenzi shengwu xuebaoRequires access

Roles of JAK/STAT Signal Pathway in Lymphoma

Zhang Qia

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Abstract

The activation of Janus kinase( JAK)/signal transducer and activator transcription( STAT) pathway,which plays an important role in tumorigenesis,is aberrantly in a variety of lymphomas.Recently,the JAK/STAT inhibitors are being considered for their potentials in the therapy for lymphoma.This review summarizes the progresses on the JAK/STAT signaling pathway in the pathogenesis of lymphoma development.The genomic alterations and the mutations of JAK kinase and STATs in different lymphoma subtypes are outlined.The effects of disregulated JAK/STAT signaling and the regulatory mechanisms in lymphomagenesis are discussed.The application of JAK/STAT inhibitors as a potential therapeutic approach for lymphoma treatment is prospected.

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What this paper is about

The activation of Janus kinase( JAK)/signal transducer and activator transcription( STAT) pathway,which plays an important role in tumorigenesis,is aberrantly in a variety of lymphomas.Recently,the JAK/STAT inhibitors are being considered for their potentials in the therapy for lymphoma.This review summarizes the progresses on the JAK/STAT signaling pathway in the pathogenesis of lymphoma development.The genomic alterations and the mutations of JAK kinase and STATs in different lymphoma subtypes are outlined.The effects of disregulated JAK/STAT signaling and the regulatory mechanisms in lymphomagenesis are discussed.The application of JAK/STAT inhibitors as a potential therapeutic approach for lymphoma treatment is prospected.

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Available abstract

The activation of Janus kinase( JAK)/signal transducer and activator transcription( STAT) pathway,which plays an important role in tumorigenesis,is aberrantly in a variety of lymphomas.Recently,the JAK/STAT inhibitors are being considered for their potentials in the therapy for lymphoma.This review summarizes the progresses on the JAK/STAT signaling pathway in the pathogenesis of lymphoma development.The genomic alterations and the mutations of JAK kinase and STATs in different lymphoma subtypes are outlined.The effects of disregulated JAK/STAT signaling and the regulatory mechanisms in lymphomagenesis are discussed.The application of JAK/STAT inhibitors as a potential therapeutic approach for lymphoma treatment is prospected.

Key concepts: stat, Janus kinase, JAK-STAT signaling pathway, STAT protein, Lymphoma, Cancer research, Signal transduction, STAT3

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