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BLOOD VOLUME CHANGES IN EXPERIMENTAL CARBON MONOXIDE POISONING

Michio Ogawa, Shuji Shimazaki, Noriaki Tanaka, Takashi Ukai, Tsuyoshi Sugimoto

Abstract

Blood volume changes were determined using 51Cr tagged red cells during and after the experimental CO exposure. Blood volume reduced by more than 20% of the initial volume during the CO exposure, and it was mainly due to the reduction of plasma volume caused by the increased vascular permeability. This hemocon-centration was reversible by the application of the hyperbaric oxygenation.Our present findings would offer a possible explanation of the hemoconcentration and its recovery by the hyperbaric oxygen therapy observed in the patients with acute CO poisoning.

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Available abstract

Key concepts: Hemoconcentration, CO poisoning, Blood volume, Plasma volume, Carbon monoxide poisoning, Volume (thermodynamics), Vascular permeability, Hyperbaric oxygenation