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Determination of vitamin D2 in multivitamin tablets by high-performance liquid chromatography

Christeen Mackay, J. Tillman, Duncan Thorburn Burns

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Abstract

A procedure is described for the determination of vitamin D2 in multi-vitamin tablets. The vitamin is released from the tablets by enzymic digestion, which is followed by solvent extraction and chromatography on a microparticulate silica column. Other fat-soluble vitamins do not interfere with the assay. The problem of defining and quantifying vitamin D2 in order to correlate results with biological potency is discussed. The procedure is suitable for stability studies.

About this research paper

What this paper is about

A procedure is described for the determination of vitamin D2 in multi-vitamin tablets. The vitamin is released from the tablets by enzymic digestion, which is followed by solvent extraction and chromatography on a microparticulate silica column. Other fat-soluble vitamins do not interfere with the assay. The problem of defining and quantifying vitamin D2 in order to correlate results with biological potency is discussed. The procedure is suitable for stability studies.

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OpenAlex reports 11 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

A procedure is described for the determination of vitamin D2 in multi-vitamin tablets. The vitamin is released from the tablets by enzymic digestion, which is followed by solvent extraction and chromatography on a microparticulate silica column. Other fat-soluble vitamins do not interfere with the assay. The problem of defining and quantifying vitamin D2 in order to correlate results with biological potency is discussed. The procedure is suitable for stability studies.

Key concepts: Multivitamin, Chromatography, Vitamin, Chemistry, Extraction (chemistry), High-performance liquid chromatography, Potency, Fat-Soluble Vitamin

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