1984•Annals of Internal MedicineRequires access
Ranitidine and Cimetidine
Marcos A. Souza Lima
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Letters and Corrections1 January 1984Ranitidine and CimetidineMARCOS A.S. LIMA, M.D.MARCOS A.S. LIMA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-1-160_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The editorial by McCarthy (1) comparing ranitidine and cimetidine is misleading in several aspects. His attempt to represent the drugs as similar has many flaws.First, he questions whether patients whose treatment fails with either drug might be effectively managed with the other drug. In fact, ranitidine does supress gastric hypersecretion in some patients who are resistent to cimetidine (2, 3). Second, the drug interactions associated with ranitidine are rare and not of the same magnitude as those seen with cimetidine, as a rule (4). This difference is due to the lesser effect of ranitidine on cytochrome-P450-mediated...References1. MCCARTHY D. Ranitidine or cimetidine [Editorial]. Ann Intern Med. 1983;99:551-3. LinkGoogle Scholar2. DANILEWITZ M, TIM L, and HIRSCHOWITZ B. Ranitidine suppression of gastric hypersecretion resistant to cimetidine. N Engl J Med. 1982;306:20-2. CrossrefMedlineGoogle Scholar3. JENSEN R, COLLEN M, and PANDOL S. Cimetidine-induced impotence and breast changes in patients with gastric hypersecretory states. N Engl J Med. 1983;308;883-7. CrossrefMedlineGoogle Scholar4. BROGDEN R, CARMINE A, and HEEL R. Ranitidine: a review of its pharmacology and therapeutic use in peptic ulcer disease and other allied disease. Drugs. 1982;24:267-303. CrossrefMedlineGoogle Scholar5. WALT R, MALE P, and RAWLINGS J. Comparison of the effects of ranitidine, cimetidine and placebo on the 24 hour intragastric acidity and nocturnal acid secretion in patients with duodenal ulcer. Gut. 1981;22:49-54. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARCOS A.S. LIMA, M.D.Affiliations: Leesburg Regional Medical Center Leesburg, FL 32748 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug-Induced CholestasisHepatitis Associated with RanitidineMARCOS A. SOUZA LIMA, M.D. 1 January 1984Volume 100, Issue 1Page: 160-161KeywordsDrug interactionsDrugs ePublished: 1 December 2008 Issue Published: 1 January 1984 PDF downloadLoading ...