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2006•Journal of Sulfur ChemistryRequires access

Halogenated, alkylated and new types of imidazolidine, pyrrolidine, imidazotriazine and thienoimidazole derivatives with biological and antitumor activities

Ahmed M. Sh. El‐Sharief, Abdulkhaliq M. Al‐Amri, Shaya Y. Al‐Raqa

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Abstract

New types of halogenated, alkylated and (bis)cyanothio-formamides were prepared and reacted with iso(thio)cyanates, aldehydes and dibenzylideneacetone to produce (bis)imidazolidine-imino(di)thiones and (oxazolidine and bispyrrolidine)iminothiones, respectively. Imidazolidineimi-nothiones were reacted with H2S/TEA to give thiohydantoin which reacted with p-chlorobenzaldehyde to achieve the corresponding thienoimidazole derivative. Most of the synthesized products exhibited antibacterial, antifungal and antitumor activities.

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What this paper is about

New types of halogenated, alkylated and (bis)cyanothio-formamides were prepared and reacted with iso(thio)cyanates, aldehydes and dibenzylideneacetone to produce (bis)imidazolidine-imino(di)thiones and (oxazolidine and bispyrrolidine)iminothiones, respectively. Imidazolidineimi-nothiones were reacted with H2S/TEA to give thiohydantoin which reacted with p-chlorobenzaldehyde to achieve the corresponding thienoimidazole derivative. Most of the synthesized products exhibited antibacterial, antifungal and antitumor activities.

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Available abstract

New types of halogenated, alkylated and (bis)cyanothio-formamides were prepared and reacted with iso(thio)cyanates, aldehydes and dibenzylideneacetone to produce (bis)imidazolidine-imino(di)thiones and (oxazolidine and bispyrrolidine)iminothiones, respectively. Imidazolidineimi-nothiones were reacted with H2S/TEA to give thiohydantoin which reacted with p-chlorobenzaldehyde to achieve the corresponding thienoimidazole derivative. Most of the synthesized products exhibited antibacterial, antifungal and antitumor activities.

Key concepts: Imidazolidine, Chemistry, Alkylation, Antifungal, Pyrrolidine, Oxazolidine, Thio-, Organic chemistry

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Halogenated, alkylated and new types of imidazolidine, pyrrolidine, imidazotriazine and thienoimidazole derivatives with biological and antitumor activities — Research Paper | ScholarLens