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A Convenient Preparation of n-Butyl Chloromethyl Ether and Its Use inOrtho-Directed Metalation of Phenols

Javid H. Zaidi

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Abstract

A simple preparation of n-butyl chloromethyl ether is described which can be extended to other alkyl chloromethyl ethers. n-Butoxymethyl ether derived from n-butyl chloromethyl ether and phenol were used to assess the effectiveness of n-butoxymethyl group in ortho-metalation.

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What this paper is about

A simple preparation of n-butyl chloromethyl ether is described which can be extended to other alkyl chloromethyl ethers. n-Butoxymethyl ether derived from n-butyl chloromethyl ether and phenol were used to assess the effectiveness of n-butoxymethyl group in ortho-metalation.

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Available abstract

A simple preparation of n-butyl chloromethyl ether is described which can be extended to other alkyl chloromethyl ethers. n-Butoxymethyl ether derived from n-butyl chloromethyl ether and phenol were used to assess the effectiveness of n-butoxymethyl group in ortho-metalation.

Key concepts: Chemistry, Metalation, Ether, Phenol, Phenols, Organic chemistry, Williamson ether synthesis, Alkyl

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