ScholarLens Back to search
1977•The Journal of AntibioticsOpen access

In vitro antimicrobial activity comparison of cefaclor (compound 99638), cephradine, and cephalothin.

Ronald N. Jones, E. Gerlach, Peter Fuchs

Open full text 6 citations

Abstract

Cefaclor [3-chloro-7-D-(2-phenylglycemamido)-3-cephem-4-carboxylic acid], has been reported by PRESTON and WICK as a new orally absorbed semi-synthetic cephalosporin (14th ICAAC Meeting, paper #426, 1974).This drug is structurally similar to the clinically available oral cephalosporins, cephradine and cephalexin.4)The significant structural difference is the substitution of a chloro group for the methyl group found in cephalexin and cephradine (Fig. 1).This study compares the in vitro antimicrobial activity of cefaclor with that of cephradine and cephalothin against seven commonly encountered bacterial species.

Open-access reader

About this research paper

What this paper is about

Cefaclor [3-chloro-7-D-(2-phenylglycemamido)-3-cephem-4-carboxylic acid], has been reported by PRESTON and WICK as a new orally absorbed semi-synthetic cephalosporin (14th ICAAC Meeting, paper #426, 1974).This drug is structurally similar to the clinically available oral cephalosporins, cephradine and cephalexin.4)The significant structural difference is the substitution of a chloro group for the methyl group found in cephalexin and cephradine (Fig. 1).This study compares the in vitro antimicrobial activity of cefaclor with that of cephradine and cephalothin against seven commonly encountered bacterial species.

Why it matters

OpenAlex reports 6 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Cefaclor [3-chloro-7-D-(2-phenylglycemamido)-3-cephem-4-carboxylic acid], has been reported by PRESTON and WICK as a new orally absorbed semi-synthetic cephalosporin (14th ICAAC Meeting, paper #426, 1974).This drug is structurally similar to the clinically available oral cephalosporins, cephradine and cephalexin.4)The significant structural difference is the substitution of a chloro group for the methyl group found in cephalexin and cephradine (Fig. 1).This study compares the in vitro antimicrobial activity of cefaclor with that of cephradine and cephalothin against seven commonly encountered bacterial species.

Key concepts: Cephradine, Cefaclor, Cephalosporin, Antimicrobial, Cephem, Chemistry, Cephalosporin Antibiotic, Antibiotics

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
In vitro antimicrobial activity comparison of cefaclor (compound 99638), cephradine, and cephalothin. — Research Paper | ScholarLens