2004•New England Journal of MedicineRequires access

Immunosuppressive Drugs for Kidney Transplantation

Philip F. Halloran

Abstract

Suppression of allograft rejection is central to successful organ transplantation; thus, immunosuppressive agents are crucial for successful allograft function. Immunosuppressive drugs are used for induction (intense immunosuppression in the initial days after transplantation), maintenance, and reversal of established rejection. This review considers the use of immunosuppressive drugs in organ transplantation, focusing on renal transplantation.

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Key concepts: Medicine, Immunosuppression, Transplantation, Kidney transplantation, Organ transplantation, Intensive care medicine, Graft rejection, Immunology