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1991•Liebigs Annalen der ChemieRequires access

Antibiotics from gliding bacteria, XLIII. Phenoxan: A novel inhibitor of HIV‐1 infection in cell cultures from Polyangium sp., strain Pl VO19 (Myxobacteria)

Rolf Jansen, Brigitte Kunze, Victor Wray, Hans Reichenbach, Elke Jurkiewicz, Gerhard Hunsmann, Gerhard Höfle

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Abstract

Abstract Guided by a biological screening with a cell assay, the first HIV‐1 inhibitor from a gliding bacterium, phenoxan (1), was isolated. The structure of 1 was determined by spectroscopic methods to be a substituted oxazole‐γ‐pyrone, showing a remarkable similarity to aureothin (2) and spectinabilin (3).

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What this paper is about

Abstract Guided by a biological screening with a cell assay, the first HIV‐1 inhibitor from a gliding bacterium, phenoxan (1), was isolated. The structure of 1 was determined by spectroscopic methods to be a substituted oxazole‐γ‐pyrone, showing a remarkable similarity to aureothin (2) and spectinabilin (3).

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Available abstract

Abstract Guided by a biological screening with a cell assay, the first HIV‐1 inhibitor from a gliding bacterium, phenoxan (1), was isolated. The structure of 1 was determined by spectroscopic methods to be a substituted oxazole‐γ‐pyrone, showing a remarkable similarity to aureothin (2) and spectinabilin (3).

Key concepts: Myxobacteria, Bacteria, Antibiotics, Microbiology, Chemistry, Strain (injury), Human immunodeficiency virus (HIV), Stereochemistry

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Antibiotics from gliding bacteria, XLIII. Phenoxan: A novel inhibitor of HIV‐1 infection in cell cultures from Polyangium sp., strain Pl VO19 (Myxobacteria) — Research Paper | ScholarLens