2011•Organic LettersRequires access

Chiral Brønsted Acid Catalysis for Enantioselective Hosomi−Sakurai Reaction of Imines with Allyltrimethylsilane

Norie Momiyama, Hayato Nishimoto, Masahiro Terada

Abstract

The chiral Brønsted acid (1b or 1c) has been shown to initiate the Hosomi-Sakurai reaction of imines with excellent enantioselectivities. The combined Brønsted acid system has been developed to offer a new class of chiral Brønsted acid catalysis. The present system proceeds through regeneration of the chiral Brønsted acid by proton transfer from additional Brønsted acid to silylated chiral Brønsted acid, a newly elucidated mechanism for the role of the additional Brønsted acid.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 60 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Chemistry, Enantioselective synthesis, Brønsted–Lowry acid–base theory, Catalysis, Organic chemistry, Combinatorial chemistry