1982•British Journal of Clinical PharmacologyOpen access
Prazosin first dose phenomenon during combined treatment with a beta‐ adrenoceptor blocker in hypertensive patients.
Peter Seideman, A. Grahnén, K. Haglund, B. Lindström, Christer von Bahr
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Abstract
1 The antihypertensive effect of prazosin has been studied in three groups of hypertensive patients. 2 The drug caused a significant reduction of blood pressure both as monotherapy and combined with alprenolol. 3 The effect of prazosin on blood pressure was more marked at the first dose and especially in combination with alprenolol. 4 No pharmacokinetic interaction between prazosin and alprenolol was observed. 5 Prazosin exhibits an exaggerated first dose effect together with alprenolol. Smaller starting doses of prazosin in combination therapy with beta-adrenoceptor blockers are warranted.