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2003•World Chinese Journal of DigestologyOpen access

Effect of sodium butyrate on the expression of cathepsins D

Xi Li, He-Sheng Luo, Fan Li

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Abstract

AIM: To detect the effect of sodium butyrate on the expression of cathepsins D(Cath-D) in HT-29 colon carcinoma cell. METHODS: MTT assay, light microscopy and immunocytochemistry were used to observe the growth, apoptosis and expression of Cath-D in HT-29 cell line after treated by sodium butyrate RESULTS: Sodium butyrate inhibited the growth of HT-29 cell lines, induced apoptosis and increased the expression of Cath-D in HT-29 cell line. CONCLUSION: Sodium butyrate can affect the expressoon of Cath-D and may play an important role in apoptosis of HT-29 cell line. Li X, Luo HS, Li F. Effect of sodium butyrate on the expression of cathepsins D. Shijie Huaren Xiaohua Zazhi 2003;11(10):1508-1510

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AIM: To detect the effect of sodium butyrate on the expression of cathepsins D(Cath-D) in HT-29 colon carcinoma cell. METHODS: MTT assay, light microscopy and immunocytochemistry were used to observe the growth, apoptosis and expression of Cath-D in HT-29 cell line after treated by sodium butyrate RESULTS: Sodium butyrate inhibited the growth of HT-29 cell lines, induced apoptosis and increased the expression of Cath-D in HT-29 cell line. CONCLUSION: Sodium butyrate can affect the expressoon of Cath-D and may play an important role in apoptosis of HT-29 cell line. Li X, Luo HS, Li F. Effect of sodium butyrate on the expression of cathepsins D. Shijie Huaren Xiaohua Zazhi 2003;11(10):1508-1510

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Available abstract

AIM: To detect the effect of sodium butyrate on the expression of cathepsins D(Cath-D) in HT-29 colon carcinoma cell. METHODS: MTT assay, light microscopy and immunocytochemistry were used to observe the growth, apoptosis and expression of Cath-D in HT-29 cell line after treated by sodium butyrate RESULTS: Sodium butyrate inhibited the growth of HT-29 cell lines, induced apoptosis and increased the expression of Cath-D in HT-29 cell line. CONCLUSION: Sodium butyrate can affect the expressoon of Cath-D and may play an important role in apoptosis of HT-29 cell line. Li X, Luo HS, Li F. Effect of sodium butyrate on the expression of cathepsins D. Shijie Huaren Xiaohua Zazhi 2003;11(10):1508-1510

Key concepts: Sodium butyrate, Butyrate, Apoptosis, Chemistry, Cell culture, Sodium, Cell, Immunocytochemistry

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