2015•Journal of Medical VirologyRequires access
Comparing Abbott m2000 RealTime HIV test and Roche COBAS Ampliprep/COBAS Taqman HIV test, v2.0 in treated HIV‐1 B and non‐B subjects with low viraemia
Apostolia Margariti, Dimitrios Chatzidimitriou, Symeon Metallidis, Dimitrios Pilalas, Andreas Kourelis, Εvangelia Papadimitriou, Anna‐Bettina Haidich, Nicolaos Malisiovas, Lemonia Skoura
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Abstract
Viral load testing is a valuable tool in HIV clinical care and research. Discrepancies among diverse viral load assays, especially with regard to non-B HIV-1 subtypes have been reported. Our study aimed to explore the impact of HIV subtype (B versus non-B) on the agreement between CAP/CTM, v2.0 and m2000 RealTime in treated HIV patients, focusing on low viral loads (<200 copies/ml). Our findings indicate that there is a significant difference in the performance of the compared assays in the low-viremic range and non-B subtypes, suggesting that a single assay should be used for follow-up.