Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry for Protein Identification Using Peptide and Fragment Ion Masses

Methods for the identification of proteins advanced dramatically in the past decade through the introduction of mass spectrometric techniques and instrumentation sensitive enough to be applicable to biological systems ( 1 , 2 ). The two mass spectrometric techniques that have provided these advantages are electrospray-ionization mass spectrometry (ESI-MS) and matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.