1989•American Journal of HypertensionOpen access
Effect of Dietary Sodium on the Na-K ATPase Inhibitor in Patients With Essential Hypertension
Terunao Ashida, Mono Kuramochi, Shunichi Kojima, Hiroki Yoshimi, Yuhei Kawano, Genjiro Kimura, Hitoshi Abe, Masahito Imanishi, Kaoru Yoshida, Minoru Kawamura, Teruo Omae
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Abstract
To study the circulating humoral factor modifying transmembrane sodium transport, plasma was obtained from 12 patients with essential hypertension (EH) fed a high sodium diet (NaCl 15 to 17 g/d) for seven days and thereafter a low sodium diet (NaCl 2 to 3 g/d) for seven days. Ouabain-sensitive 86Rb+ influx into the red blood cells (RBC) obtained from a healthy subject, and incubated with the plasma obtained during the high sodium diet was significantly lower than that incubated with the plasma obtained during the low sodium diet (3.74 +/- 0.26 v 3.97 +/- 0.30 nmol/10(8) cells, P less than .05). The changes in mean blood pressure from the high to low sodium diet showed a significant positive correlation with the changes in the ouabain-sensitive Rb influx into RBC in the plasma from the high to low sodium diet. These results suggest that a humoral factor modifying the sodium pump might be altered by sodium balance in EH, especially in salt-sensitive hypertension.