2009•Zhongguo Yike Daxue xuebaoRequires access

Effect of GDNF on COX-2 expression in rat hippocampus after focal cerebral ischemia.

Zhou TieZhu, Fu Xia

Abstract

Objective To observe the effect of glial cell-lined derived neurotrophic factor(GDNF)on cyclooxygenase-2(COX-2)expression after focal cerebral ischemia/reperfusion injury.Methods The rat model of middle cerebral artery occlusion(MACO)was established by intraluminal suture method.GDNF was injected into the lateral ventricle under stereo localization.The expression of COX-2 in the hippocampus was detected in model group,control group,and GDNF group.Results The expression of COX-2 was significantly lower in GDNF group than in model group and control group(P 0.05).Conclusion GDNF may protect brain tissue from ischemic injury by decreasing of the expression of COX-2.

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Key concepts: Glial cell line-derived neurotrophic factor, Ischemia, Medicine, Neurotrophic factors, Hippocampus, Ventricle, Occlusion, Immunohistochemistry