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TERFENADINE-KETOCONAZOLE INTERACTION: PHARMACOKINETIC AND ELECTROCARDIOGRAPHIC CONSEQUENCES

Alan B. Goldsobel

Open publisher page 3 citations

Abstract

Ketoconazole alters the metabolism of terfenadine in normal men and women. This results in accumulation of the parent drug, and is associated with significant prolongation of QTc. This drug combination should be avoided.

About this research paper

What this paper is about

Ketoconazole alters the metabolism of terfenadine in normal men and women. This results in accumulation of the parent drug, and is associated with significant prolongation of QTc. This drug combination should be avoided.

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OpenAlex reports 3 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Ketoconazole alters the metabolism of terfenadine in normal men and women. This results in accumulation of the parent drug, and is associated with significant prolongation of QTc. This drug combination should be avoided.

Key concepts: Terfenadine, Ketoconazole, Medicine, Pharmacokinetics, Astemizole, Pharmacology, QT interval, Drug

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TERFENADINE-KETOCONAZOLE INTERACTION: PHARMACOKINETIC AND ELECTROCARDIOGRAPHIC CONSEQUENCES — Research Paper | ScholarLens