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Start and end of the effects of terfenadine and astemizole on histamine-induced wheals in human skin.

H Työlahti, A. Lahti

Abstract

A study was made of effects of two antihistamines, terfenadine (60 mg twice daily) and astemizole (10 mg once daily) on wheals induced by histamine dihydrochloride (10 mg/ml) in the prick test on the upper back of 15 healthy students. The suppressive effects of terfenadine on the histamine wheal appeared earlier (2 h), and disappeared earlier (within 1 day) than those of astemizole (3 days and 28 days, respectively). No difference between the maximal effects of the two drugs was seen.

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Key concepts: Terfenadine, Astemizole, Histamine, Histamine H1 receptor, Pharmacology, Medicine, Anesthesia, Internal medicine