Study on the effect of Actara and Confidor on rabbits submited to chronic intoxication.

Actara and Confidor are neonicotinoid products of a new large insecticide class, its active substances being organic compounds obtained synthetically. The available data about the effect of the neonicotinoid insecticides on vertebrates are quite limited. The aim of the present study was to establish the effect of Actara and Confidor on rabbits submitted to chronic intoxication, by carrying out biochemical blood analysis (blood glucose, total protein, cholesterol, APh, ASAT, ALAT) and by ethological observations. Two experimental groups and a control group were formed. Every morning 50 mg of Actara per kg of live weight of the rabbits in group О2 and 4,6 mg/kg in group О1 was added to the food for a 45-day period. On 46th day blood was taken from all the animals by marginal ear vein puncture. Chronic treatment of the rabbits with the neonicotinoid insecticides Actara and Confidor causes a statistically significant increase of the blood glucose values, increases the activities of ASAT and APh and decreases the total protein values. The behavior observed was not different from physiological one.