2009•Xiandai shengwu yixue jinzhanRequires access
Clinical significance of 5 serum markers in diagnosis of breast cancer.
Hongbo Gao, Gong Ping, Li Na, Ning Guo, Jing Fei, Huang Wei, Zhenhua Wang
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Abstract
Objective:To investigate the clinical value of detecting five serum marker:CEA,CA15-3,CA12-5,TPS and VEGF in different combination for diagnosis of breast cancer.Methods:The five serum markers were detected by enzyme linked immunosorbent assay in 53 cases of breast cancer and 50 cases of benign breast diseases and 50 cases in normal control group.Results:The serum levels of 5 tumor markers in breast cancer patients were significantly higher than those in the benign breast disease in the control group.the sensitivity of breast cancer by detecting the serum markers respectively was 56.6%,35.8%,30.2%,26.4%and 37.75%,and that was 71.7% by TPS plus CA15-3.Conclusion:The serum markers CEA,CA15-3,CA12-5,TPSandVEGF were much more sensitive markers,and the combined detection of CA15-3 and TPS was an effective method in screening breast cancer and their combined detection can significantly improve the sensitivity of breast cancer diagnosis.