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Acetaminophen Hepatotoxicity After a Prolonged Ingestion

Philip D. Walson, John F. Groth

Open publisher page 4 citations

Abstract

To the Editor.— The Rumack-Matthew nomogram has been useful in predicting hepatotoxicity following single, acute acetaminophen ingestions.1 We report a case of acetaminophen hepatotoxicity to emphasize the lack of predictive value of the nomogram if the ingestion occurs during a prolonged period. A 16-year-old girl reportedly ingested between 7.5 and 10 g of acetaminophen during a 4-hour period (7:00 to 11:00 am). She vomited twice spontaneously between 11:00 am and 3:30 pm A serum acetaminophen concentration drawn at 3:15 pm was 114 mg/L.

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What this paper is about

To the Editor.— The Rumack-Matthew nomogram has been useful in predicting hepatotoxicity following single, acute acetaminophen ingestions.1 We report a case of acetaminophen hepatotoxicity to emphasize the lack of predictive value of the nomogram if the ingestion occurs during a prolonged period. A 16-year-old girl reportedly ingested between 7.5 and 10 g of acetaminophen during a 4-hour period (7:00 to 11:00 am). She vomited twice spontaneously between 11:00 am and 3:30 pm A serum acetaminophen concentration drawn at 3:15 pm was 114 mg/L.

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Available abstract

To the Editor.— The Rumack-Matthew nomogram has been useful in predicting hepatotoxicity following single, acute acetaminophen ingestions.1 We report a case of acetaminophen hepatotoxicity to emphasize the lack of predictive value of the nomogram if the ingestion occurs during a prolonged period. A 16-year-old girl reportedly ingested between 7.5 and 10 g of acetaminophen during a 4-hour period (7:00 to 11:00 am). She vomited twice spontaneously between 11:00 am and 3:30 pm A serum acetaminophen concentration drawn at 3:15 pm was 114 mg/L.

Key concepts: Medicine, Acetaminophen, Ingestion, Nomogram, Anesthesia, Gastroenterology, Internal medicine

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