2010•Asian Journal of Research in ChemistryRequires access

Spectrophotometric Estimation of Tramadol Hydrochloride in Bulk and Tablet Dosage Form

S.R. Bavaskar, Abhishek Agrawal, Yogesh S. Agrawal, Amol Amrutkar, Niraj L. Badhe, P.S. Kawatikwar

Abstract

A simple, sensitive, accurate and precise UV Spectrophotometric method has been developed for quantitative determination of Tramadol Hydrochloride in bulk and tablet formulations. The UV-spectrum was scanned between 220 to 400 nm and 270.5 nm was selected as maximum wavelength for absorption. Tramadol shows molar absorptivity of 1.771×104l/mol/cm and Sandell's sensitivity 0.16927mcg/Sq.cm/0.001-absorbance units. Beer's law was obeyed in the concentration range of 15–170 μg/ml. Results of analysis were validated statistically and by recovery studies.

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Key concepts: Molar absorptivity, Tramadol Hydrochloride, Absorbance, Dosage form, Absorption (acoustics), Spectrophotometry, Chromatography, Chemistry