Membrane‐Associated Fatty Acid Binding Proteins Regulate Fatty Acid Uptake by Cardiac and Skeletal Muscle
Jan F. C. Glatz, Joost J.F.P. Luiken, Ger J. Vusse, Arend Bonen
Abstract
Jan F. C. Glatz, Joost J.F.P. Luiken, Ger J. Vusse, Arend Bonen
Abstract
Introduction Molecular Mechanism of Muscular Fatty Acid Uptake Passive Diffusional and Protein-mediated Fatty Acid Uptake Membrane-associated Fatty Acid Binding Proteins Putative Mechanism of Cellular Fatty Acid Uptake Expression of FABPs in Heart and Skeletal Muscles Compared Regulation of Muscular Fatty Acid Uptake Acute Changes in Muscle Fatty Acid Utilization and Membrane FABPs Signaling Pathway for FAT/CD36 Translocation to and from the Sarcolemma Chronic Changes in Muscle Fatty Acid Utilization and Membrane FABPs Concerted Action of the Proteins Involved in Muscle Fatty Acid Uptake Alterations in Fatty Acid Uptake and Membrane FABPs in Disease Concluding Remarks Acknowledgements References
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Introduction Molecular Mechanism of Muscular Fatty Acid Uptake Passive Diffusional and Protein-mediated Fatty Acid Uptake Membrane-associated Fatty Acid Binding Proteins Putative Mechanism of Cellular Fatty Acid Uptake Expression of FABPs in Heart and Skeletal Muscles Compared Regulation of Muscular Fatty Acid Uptake Acute Changes in Muscle Fatty Acid Utilization and Membrane FABPs Signaling Pathway for FAT/CD36 Translocation to and from the Sarcolemma Chronic Changes in Muscle Fatty Acid Utilization and Membrane FABPs Concerted Action of the Proteins Involved in Muscle Fatty Acid Uptake Alterations in Fatty Acid Uptake and Membrane FABPs in Disease Concluding Remarks Acknowledgements References
Key concepts: Fatty acid-binding protein, Fatty acid, Sarcolemma, CD36, adipocyte protein 2, Free fatty acid receptor, Biochemistry, Skeletal muscle