MACROCYTIC ANEMIA, OTHER THAN PERNICIOUS ANEMIA, ASSOCIATED WITH LESIONS OF THE GASTROINTESTINAL TRACT

Article1 February 1939MACROCYTIC ANEMIA, OTHER THAN PERNICIOUS ANEMIA, ASSOCIATED WITH LESIONS OF THE GASTROINTESTINAL TRACTCYRUS C. STURGIS, M.D., F.A.C.P., S. MILTON GOLDHAMER, M.D.CYRUS C. STURGIS, M.D., F.A.C.P.Search for more papers by this author, S. MILTON GOLDHAMER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-8-1245 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA macrocytic anemia may be defined as an anemia in which there is an increase in the number of red blood cells of the circulating blood having a diameter greater than 7.5 microns, and a mean corpuscular volume which exceeds 96 cubic microns. In such an anemia the color index usually is one or higher. It is generally considered to be due to defective blood formation and is frequently controlled by anti-pernicious anemia medication but is not ordinarily benefited by iron therapy.An anemia of this type is characteristically found in true Addisonian pernicious anemia, in the so-called "tropical anemia"...Bibliography1. CASTLE WB: Observation on the etiologic relationship of achylia gastrica to pernicious anemia. I. The effect of the administration to patients with pernicious anemia of the contents of the normal human stomach recovered after the ingestion of beef muscle, Am. Jr. Med. Sci., 1929, clxxviii, 746. Google Scholar2. CASTLETOWNSEND WBWC: Observation on the etiologic relationship of achylia gastrica to pernicious anemia. II. The effect of the administration to patients with pernicious anemia of beef muscle after incubation with normal human gastric juice, Am. Jr. Med. Sci., 1929, clxxviii, 764. CrossrefGoogle Scholar3. CASTLETOWNSENDHEATH WBWCCW: Observation on the etiologic relationship of achylia gastrica to pernicious anemia. III. The nature of the reaction between normal human gastric juice and beef muscle leading to clinical improvement and increased blood formation similar to the effect of liver feeding, Am. Jr. Med. Sci., 1930, clxxx, 305. CrossrefGoogle Scholar4. CASTLEHEATHSTRAUSS WBCWMB: Observations on the etiologic relationship of achylia gastrica to pernicious anemia. IV. A biologic assay of the gastric secretion of patients with pernicious anemia having free hydrochloric acid and that of patients without anemia or with hypochromic anemia having no free hydrochloric acid, and of the rôle of intestinal impermeability to hematopoietic substances in pernicious anemia, Am. Jr. Med. Sci., 1931, clxxxii, 741. CrossrefGoogle Scholar5. MEULENGRACHT E: Pernicious anemia in intestinal stricture, Acta Med. Scand., 1929, lxxii, 231. Google Scholar6. MEULENGRACHT E: The presence of the anti-anemic factor in preparations of dried stomach substance from the cardia, fundus and pylorus respectively, Acta Med. Scand., 1934, lxxxii, 352. Google Scholar7. MEULENGRACHTOHLSEN EAS: The topographical distribution of the glands of the cardia, fundus and pylorus in the stomach of the pig, Acta Med. Scand., 1934, lxxxii, 384. Google Scholar8. MEULENGRACHT E: Continued investigations on the presence of the antianaemic factor in preparations of dried stomach substance from the cardia, fundus and pylorus regions. IV. Preparations from the cardia region, Acta Med. Scand., 1935, lxxxv, 50. Google Scholar9. MEULENGRACHT E: Continued investigations on the presence of the antianaemic factor in preparations of dried stomach substance from the cardia, fundus and pylorus, and the duodenum. V. Preparations from the duodenum, Acta Med. Scand., 1935, lxxxv, 79. Google Scholar10. GOLDHAMER SM: Relationship between gastric juice volume and erythropoiesis in patients with untreated pernicious anemia, Proc. Soc. Exper. Biol. and Med., 1934, xxxii, 476. CrossrefGoogle Scholar11. GOLDHAMER SM: The presence of the intrinsic factor of Castle in the gastric juice of patients with pernicious anemia, Am. Jr. Med. Sci., 1936, cxci, 405. CrossrefGoogle Scholar12. GOLDHAMER SM: The gastric juice in patients with pernicious anemia in induced remission, Am. Jr. Med. Sci., 1937, cxciii, 23. CrossrefGoogle Scholar13. GOLDHAMERISAACSSTURGIS SMRCC: The rôle of the liver in hematopoiesis, Am. Jr. Med. Sci., 1934, clxxxviii, 193. CrossrefGoogle Scholar14. GOLDHAMER SM: Liver extract therapy in cirrhosis of the liver. Relation of liver dysfunction to non-storage of "anti-anemic" substance in producing a blood picture resembling pernicious anemia in a patient secreting free hydrochloric acid, Arch. Int. Med., 1934, liii, 54. CrossrefGoogle Scholar15. RICHTERIVYKIM OACMS: Action of human "pernicious anemia liver extract," Proc. Soc. Exper. Biol. and Med., 1932, xxix, 1093. CrossrefGoogle Scholar16. GOODMANGEIGARCLAIBORN LAJLN: Anti-anemia potency of liver after gastrectomy in swine, Proc. Soc. Exper. Biol. and Med., 1935, xxxii, 810. CrossrefGoogle Scholar17. FOUTSHELMERZERFAS PJOMLG: The formation of a hematopoietic substance in concentrated human gastric juice, Am. Jr. Med. Sci., 1934, clxxxvii, 36. CrossrefGoogle Scholar18. HELMERFOUTSZERFAS OMPJLG: The relationship of the intrinsic factor to a hematopoietic material in concentrated human gastric juice, Am. Jr. Med. Sci., 1934, clxxxviii, 184. CrossrefGoogle Scholar19. FOUTSHELMERZERFAS PJOMLG: Gastrointestinal studies. VI. The volume of the gastric juice in pernicious anemia, Am. Jr. Digest. Dis. and Nutr., 1937, iii, 904. Google Scholar20. WINTROBESHUMACHER MMHS: The occurrence of macrocytic anemia in association with disorder of the liver, Bull. Johns Hopkins Hosp., 1933, lii, 387. Google Scholar21. CASTLERHOADSLAWSONPAYNE WBCPHAGC: Etiology and treatment of sprue: observations on patients in Puerto Rico and subsequent experiments on animals, Arch. Int. Med., 1935, lvi, 627. CrossrefGoogle Scholar22. BUTTWATKINS HRCH: Occurrence of macrocytic anemia in association with lesions of the bowel, ANN. INT. MED., 1936, x, 222. Google Scholar23. UNGLEYMOFFETT CCR: Observations on Castle's intrinsic factor in pernicious anemia, Lancet, 1936, i, 1232. CrossrefGoogle Scholar24. UNGLEY CC: The effect of yeast and wheat embryo in anemias. I. Marmite, Yestamin, and Bemax in megalocytic and nutritional hypochromic anemias, Quart. Jr. Med., 1933, ii, 381. Google Scholar25. UNGLEYJAMES CCGV: The effect of yeast and wheat embryo in anemias. II. The nature of the hematopoietic factor in yeast effective in pernicious anemia, Quart. Jr. Med., 1934, iii, 523. CrossrefGoogle Scholar26. DAVIDSON LS: Autolysed yeast products in the treatment of anemia, Brit. Med. Jr., 1933, ii, 481. CrossrefGoogle Scholar27. RUSSELL HK: Hematological response of Addisonian pernicious anemia to brewer's yeast, ANN. INT. MED., 1934, vii, 1398. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*Delivered before the American College of Physicians, New York City, April 7, 1938.From the Thomas Henry Simpson Memorial Institute for Medical Research, University of Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPostgastrectomy problemsDELAYED DEVELOPMENT OF PERNICIOUS ANEMIA FOLLOWING GASTRECTOMY; HIGH FAMILIAL INCIDENCE OF CANCER: AN ILLUSTRATIVE CASE*MARTIN L. CHARLES, M.D., LOUIS J. VORHAUS, M.D.Undesirable Sequelae of Subtotal Gastric ResectionAbsorption of Radioactive Vitamin B12 after Total GastrectomyAchylia gastrica: Keystone in the development and eradication of macrocytic achylic anemia (Pernicious anemia, Addison-Biermer)Experimental studies on production of pernicious anemia by operation on the digestive tract1Die Erkrankungen des erythrocytären SystemsClinical evaluation of GastritisThe problem of gastrectomy and the anemias 1 February 1939Volume 12, Issue 8Page: 1245-1262KeywordsAnemiaBloodBlood cellsBlood volumeGastrointestinal tractLesionsMean corpuscular volumePernicious anemiaRed blood cells ePublished: 1 December 2008 Issue Published: 1 February 1939 PDF downloadLoading ...