Neurologic Disturbances with Folic Acid Therapy

THERE are numerous reports in the literature of the past two years on the excellent results obtained with folic acid in the treatment of pernicious anemia, sprue and nutritional macrocytic anemias. The observations presented below suggest some limitations of the therapeutic value of folic acid‡ and indicate that its use, in the present state of knowledge, for the treatment of pernicious anemia entails a definite risk.Material and ObservationsFourteen cases of macrocytic anemia, 10 of pernicious anemia, 1 of tropical sprue, 2 of nontropical sprue, and 1 of macrocytic anemia associated with total gastrectomy were studied. Pernicious Anemia Cases . . .