Claudio Giordano, Marco Villa, Rita Annunziata
Abstract
A new practical method for large scale preparation of 2-acyl-6-methoxynaphthalenes 3 is reported. The selectivity toward 3 is due to reversibility of the Friedel-Crafts acylation and to the thermodynamic stability of 3.
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A new practical method for large scale preparation of 2-acyl-6-methoxynaphthalenes 3 is reported. The selectivity toward 3 is due to reversibility of the Friedel-Crafts acylation and to the thermodynamic stability of 3.
Key concepts: Friedel–Crafts reaction, Chemistry, Acylation, Selectivity, Organic chemistry, Catalysis