2008•Methods and principles in medicinal chemistryRequires access
hERG Channel Physiology and Drug‐Binding Structure–Activity Relationships
Sarah Dalibalta, John S. Mitcheson
Open publisher page 7 citations
Abstract
This chapter contains sections titled: Introduction hERG Channel Structure hERG Potassium Channels and the Cardiac Action Potential Mutations in hERG Are Associated with Cardiac Arrhythmias Acquired Long QT Syndrome Drug-Binding Site of hERG Structural Basis for hERG Block Alternative Mechanisms of Block Role of Inactivation in hERG Block Inhibition of hERG Trafficking by Pharmacological Agents Computational Approaches to Predict hERG K+ Channel Block Conclusions References