2011•PubMedRequires access

Clozapine vs. other atypical antipsychotics for schizophrenia.

Clarissa Calliope Kripke

Abstract

Although further trials are needed, there is some evidence that clozapine is slightly more effective than risperidone (Risperdal). Fewer participants taking clozapine dropped out of studies because of lack of effectiveness compared with those taking risperidone (number needed to treat = 11; 95% confidence interval [CI], 7 to 21). However, adverse effects led to a higher attrition rate in patients taking clozapine than those taking olanzapine (Zyprexa; number needed to harm = 25; 95% CI, 15 to 73) and risperidone (number needed to harm = 16; 95% CI, 9 to 59). Clozapine is associated with more sedation and hypersalivation than olanzapine, quetiapine (Seroquel), and risperidone; more seizures than olanzapine and risperidone; and more weight gain than risperidone.

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Available abstract

Key concepts: Risperidone, Olanzapine, Medicine, Clozapine, Quetiapine, Adverse effect, Extrapyramidal symptoms, Schizophrenia (object-oriented programming)