2015•Pediatric Allergy Immunology and PulmonologyRequires access
Decreased CD5 − CD19 + CD27 + CD43 + CD70 − B-Cell Subpopulation in Children with Specific Antibody Deficiency
Kathryn D. Convers, Barbara Kariuki, Alan Paul Knutsen
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Abstract
Purpose: Recent studies have reported that CD19 + CD20 + CD27 + CD43 + CD70 - CD5 − B cells produce IgG, IgA, and IgM antibodies to Streptococcus pneumoniae (Spn). In one adult patient with specific antibody deficiency (SAD), the percentage of CD5 − CD19 + CD20 + CD27 + CD43 + CD70 − B cells was decreased. The percentages of CD5 − of CD19 + CD27 + CD43 + CD70 − B cells in children with SAD were examined in this study. Methods: Clinical and immunologic studies were obtained from a review of medical records. The percentages of CD5 − of CD19 + CD27 + CD43 + CD70 − B cells were determined by flow cytometry. Results: Patients with SAD had significantly decreased percentages of CD5 − of CD19 + CD27 + CD43 + CD70 − B cells. There was a significant correlation between decreased percentage of CD5 − of CD19 + CD27 + CD43 + CD70 − B cells and decreased percentage of protective antibody titers to Spn. Conclusion: Decreased percentage of CD5 − of CD19 + CD27 + CD43 + CD70 − B cells were identified in patients with SAD and correlated with decreased antibody responses to Spn.