Significance of Immunophenotype in Differential Diagnosis of Chronic B Lymphocyte Proliferation Disease

Based on the immunophenotype,chronic B lymphocyte proliferation disease can be categorized into different isoforms. Immunophenotype plays an important role in diagnosis and differential diagnosis of all subtypes. The typical( chronic) immunophenotype of B-CLL are CD5 +,CD23 +,FMC-7+. HCL specifically expresses CD22,CD25,CD103and CD11c. FL mainly expresses CD20,CD10,CD22and CD79a,but it doesn't express CD5. MCL over-expresses CD5 +,FMC7+,Bcl-2+and cyclinD1+. Typical WM doesn't express CD5 and CD23,but the variant does. The typical immunophenotype of MZL are CD5-,CD10-,CD23-and cyclinD1-. As for variants of BclPD,pathology,genetics,molecular biology should be correlated for diagnosis, so as to guide the clinical treatment and prognosis.