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Hypofibrinogenemia Due to L-Asparaginase: Studies of Fibrinogen Survival Using Autologous 131I-Fibrinogen

Richard E. Bettigole, E. S. HIMELSTEIN, Herbert Friedrich Oettgen, George O. Clifford

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Abstract

Abstract Plasma fibrinogen levels fall, often dramatically, in patients receiving L-asparaginase. Studies of six patients using autologous 131I-fibrinogen showed that at a dose of 1000 I.U./kg./day L-asparaginase had no effect on their rates of fibrinogen disappearance. The fall in their plasma fibrinogen levels, therefore, must have been a result of decreased synthesis since it could not be ascribed to increased utilization or destruction of fibrinogen.

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Abstract Plasma fibrinogen levels fall, often dramatically, in patients receiving L-asparaginase. Studies of six patients using autologous 131I-fibrinogen showed that at a dose of 1000 I.U./kg./day L-asparaginase had no effect on their rates of fibrinogen disappearance. The fall in their plasma fibrinogen levels, therefore, must have been a result of decreased synthesis since it could not be ascribed to increased utilization or destruction of fibrinogen.

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Available abstract

Abstract Plasma fibrinogen levels fall, often dramatically, in patients receiving L-asparaginase. Studies of six patients using autologous 131I-fibrinogen showed that at a dose of 1000 I.U./kg./day L-asparaginase had no effect on their rates of fibrinogen disappearance. The fall in their plasma fibrinogen levels, therefore, must have been a result of decreased synthesis since it could not be ascribed to increased utilization or destruction of fibrinogen.

Key concepts: Hypofibrinogenemia, Fibrinogen, Medicine, Internal medicine, Afibrinogenemia, Endocrinology, Immunology

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