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1971•The Journal of ImmunologyRequires access

Local Immunologic Response to Immunization with Inactivated Newcastle Disease Virus

Zichriya Zakay-Rones, Ronald Levy, G. Spira

Open publisher page 25 citations

Abstract

Abstract Chickens were immunized with Newcastle disease virus inactivated by β propriolactone. The antigen was administered by the intramuscular or intranasal route, and the appearance of HI antibodies in the serum and lungs was followed. Local secretory antibodies in the lung were found only as a consequence of intranasal immunization, whereas serum antibodies were found after administration of antigen by either route.

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What this paper is about

Abstract Chickens were immunized with Newcastle disease virus inactivated by β propriolactone. The antigen was administered by the intramuscular or intranasal route, and the appearance of HI antibodies in the serum and lungs was followed. Local secretory antibodies in the lung were found only as a consequence of intranasal immunization, whereas serum antibodies were found after administration of antigen by either route.

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Available abstract

Abstract Chickens were immunized with Newcastle disease virus inactivated by β propriolactone. The antigen was administered by the intramuscular or intranasal route, and the appearance of HI antibodies in the serum and lungs was followed. Local secretory antibodies in the lung were found only as a consequence of intranasal immunization, whereas serum antibodies were found after administration of antigen by either route.

Key concepts: Newcastle disease, Nasal administration, Immunization, Antibody, Antigen, Virology, Virus, Immunology

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