Destruction of Virus Hemagglutination Inhibitor of Egg-White by Newcastle Disease Virus.

Studies were made on the presence and mucinase activity of Newcastle disease virus and of the stability of this enzyme function to formalin. (1) All strains of Newcastle disease virus studied possessed mucinase activity although the rates at which they inactivated egg-white inhibitor differed greatly. (2) The rate at which egg-white inhibitor was inactivated was dependent on enzyme (virus) concentration. The concentration of egg-white inhibitor also affected the rate of its inactivation. (3) The rate of inactivation by Newcastle disease strains of virus could be correlated only with one known property—its rate of elution from red blood cells. (4) Newcastle disease virus mucinase was fairly stable to formalin.