1972•The Journal of ImmunologyRequires access

Inhibition of Antichlamydial IgM Antibody by IgG Antibody in Immunofluorescence Tests

S. Vern Juchau, William D. Linscott, Julius Schachter, Ernest Jawetz

Abstract

Abstract Monkeys inoculated intramuscularly with chlamydial suspensions responded with antibody demonstrable by indirect immunofluorescence. IgM antibody was not detected in the whole sera of five of six monkeys, but antibody activity could be demonstrated in IgM fractions from these sera. Monkeys inoculated intravenously with large numbers (1011) of chlamydial particles had IgM antibody detectable in whole sera as well as in fractions. IgG antibody interfered with the demonstration of IgM antibody by immunofluorescence. It is suggested that similar interference of IgG with IgM antibody may occur in other systems.

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Key concepts: Antibody, Immunofluorescence, Direct fluorescent antibody, Immunoglobulin M, Indirect immunofluorescence, Biology, Virology, Immunoglobulin G