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2005•Acta Scientiarum Naturalium Universitatis SunyatseniRequires access

Physicochemical Characterization of Veronicafolin-β-cyclodextrin and Solubility Enhancement of Veronicafolin-HP-β-cyclodextrin Inclusion Compound

杨云裳, 张应鹏, 杨爱梅, 鲁润华, 师彦平, 史高峰

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Abstract

Inclusion complexation between veronicafolin, 3,5,4'-trihydroxy-6,7,3'-trimethoxyflavone, and β-cyclodextrin(β-CD) was investigated by using ^1H NMR, IR, X-ray diffraction, thermo gravimetric analysis (TGA), and elemental analysis in the solid state. The elemental analysis showed that the complex (1:1) of flavonol-β-CD,20H2O withC 39.58% and H 5.75% has been formed. The phase solubility profile of the favonol by UV-Vis in solution in the presence of hydroxypfropyl-β-cyclodextrin (HP-β-CD) was classified as AL-type, indicating the formation of 1：1 inclusion complex. And the calibration equation y=24148x+0.0075 (r=0.9999) and phase-solubility diagram y=0.4738x-2.0×10^-7 (r=0.9490) were obtained. Stability constant Ks was calculated from the phase solubility diagram (Ks=4.5×10^6). Solubility of the veronicafolin was enhanced in the presence of HP-β-CD.

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What this paper is about

Inclusion complexation between veronicafolin, 3,5,4'-trihydroxy-6,7,3'-trimethoxyflavone, and β-cyclodextrin(β-CD) was investigated by using ^1H NMR, IR, X-ray diffraction, thermo gravimetric analysis (TGA), and elemental analysis in the solid state. The elemental analysis showed that the complex (1:1) of flavonol-β-CD,20H2O withC 39.58% and H 5.75% has been formed. The phase solubility profile of the favonol by UV-Vis in solution in the presence of hydroxypfropyl-β-cyclodextrin (HP-β-CD) was classified as AL-type, indicating the formation of 1：1 inclusion complex. And the calibration equation y=24148x+0.0075 (r=0.9999) and phase-solubility diagram y=0.4738x-2.0×10^-7 (r=0.9490) were obtained. Stability constant Ks was calculated from the phase solubility diagram (Ks=4.5×10^6). Solubility of the veronicafolin was enhanced in the presence of HP-β-CD.

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Available abstract

Inclusion complexation between veronicafolin, 3,5,4'-trihydroxy-6,7,3'-trimethoxyflavone, and β-cyclodextrin(β-CD) was investigated by using ^1H NMR, IR, X-ray diffraction, thermo gravimetric analysis (TGA), and elemental analysis in the solid state. The elemental analysis showed that the complex (1:1) of flavonol-β-CD,20H2O withC 39.58% and H 5.75% has been formed. The phase solubility profile of the favonol by UV-Vis in solution in the presence of hydroxypfropyl-β-cyclodextrin (HP-β-CD) was classified as AL-type, indicating the formation of 1：1 inclusion complex. And the calibration equation y=24148x+0.0075 (r=0.9999) and phase-solubility diagram y=0.4738x-2.0×10^-7 (r=0.9490) were obtained. Stability constant Ks was calculated from the phase solubility diagram (Ks=4.5×10^6). Solubility of the veronicafolin was enhanced in the presence of HP-β-CD.

Key concepts: Solubility, Cyclodextrin, Chemistry, Elemental analysis, Phase diagram, Inclusion compound, Phase (matter), Thermogravimetric analysis

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Physicochemical Characterization of Veronicafolin-β-cyclodextrin and Solubility Enhancement of Veronicafolin-HP-β-cyclodextrin Inclusion Compound — Research Paper | ScholarLens