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Environmental Carcinogens and Mutagens

Edward L. Loechler

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Abstract

Abstract Environmental agents (chemicals, radiation and viruses) can be carcinogens (cancer‐causing substances) and mutagens (substances that alter DNA). The steps from mutagen/carcinogen to tumour involve mutagen/carcinogen activation by metabolism, reaction with DNA to give a DNA adduct and DNA replication of the adduct, resulting in a mutation; a mutation in a cancer gene may result in enhanced growth potential, and ultimately in tumour growth.

About this research paper

What this paper is about

Abstract Environmental agents (chemicals, radiation and viruses) can be carcinogens (cancer‐causing substances) and mutagens (substances that alter DNA). The steps from mutagen/carcinogen to tumour involve mutagen/carcinogen activation by metabolism, reaction with DNA to give a DNA adduct and DNA replication of the adduct, resulting in a mutation; a mutation in a cancer gene may result in enhanced growth potential, and ultimately in tumour growth.

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Available abstract

Abstract Environmental agents (chemicals, radiation and viruses) can be carcinogens (cancer‐causing substances) and mutagens (substances that alter DNA). The steps from mutagen/carcinogen to tumour involve mutagen/carcinogen activation by metabolism, reaction with DNA to give a DNA adduct and DNA replication of the adduct, resulting in a mutation; a mutation in a cancer gene may result in enhanced growth potential, and ultimately in tumour growth.

Key concepts: Carcinogen, Mutagen, DNA, Mutagenesis, Chemistry, DNA adduct, DNA damage, Adduct

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