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2013•Research Journal of Pharmaceutical Dosage Forms and TechnologyRequires access

Development and Validation of UV–Spectrophotometric Method of Pantoprazole in bulk and Pharmaceutical dosage form

B. Siddartha, I. Sudheer Babu, Parthiban Chokkalingam, C. Madhavi

Open publisher page 3 citations

Abstract

A simple, precise and accurate UV Spectrophotometric method has been developed for estimation of Pantoprazole in bulk and tablet dosage form. In this method Pantoprazole shows λmax at 295nm using 0.1N NaOH as a solvent and calibration graphs were plotted over the concentrations ranging from 1 to 20μg/ml of Pantoprazole with correlation coefficient 0.999. The proposed method was validated as per ICH Q2 (R1) guidelines for precision, linearity, accuracy and recovery. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.083μg/ml and 0.250μg/ml respectively by simple UV spectroscopy.

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What this paper is about

A simple, precise and accurate UV Spectrophotometric method has been developed for estimation of Pantoprazole in bulk and tablet dosage form. In this method Pantoprazole shows λmax at 295nm using 0.1N NaOH as a solvent and calibration graphs were plotted over the concentrations ranging from 1 to 20μg/ml of Pantoprazole with correlation coefficient 0.999. The proposed method was validated as per ICH Q2 (R1) guidelines for precision, linearity, accuracy and recovery. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.083μg/ml and 0.250μg/ml respectively by simple UV spectroscopy.

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Available abstract

A simple, precise and accurate UV Spectrophotometric method has been developed for estimation of Pantoprazole in bulk and tablet dosage form. In this method Pantoprazole shows λmax at 295nm using 0.1N NaOH as a solvent and calibration graphs were plotted over the concentrations ranging from 1 to 20μg/ml of Pantoprazole with correlation coefficient 0.999. The proposed method was validated as per ICH Q2 (R1) guidelines for precision, linearity, accuracy and recovery. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.083μg/ml and 0.250μg/ml respectively by simple UV spectroscopy.

Key concepts: Pantoprazole, Dosage form, Detection limit, Chromatography, Correlation coefficient, Pharmaceutical formulation, Mathematics, Linearity

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