2013•Asian Journal of Research in ChemistryRequires access

Development and Validation of Simultaneous Equation UV-Spectrophotometric Method for the Estimation of Telmisartan and Amlodipine besylate in Combined Dosage Form

Shishir Maheshwari, Preeti Tiwari, Atul Srivastav

Abstract

A simple, sensitive, precise and specific UV spectrophotometric method for simultaneous estimation of Telmisartan and Amlodipine besylate in combine dosage form has been developed. The wavelengths 238 nm and 295 nm were selected for estimation of Amlodipine besylate and Telmisartan respectively, where Methanol was used as solvent. Linearity were observed in the concentration range of 2–25 μg/ml (r2=0.9994) and 2–30 μg/ml (r2=0.9999) for Telmisartan and Amlodipine besylate respectively. These methods were validated according to ICH guidelines.

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Key concepts: Telmisartan, Amlodipine, Chromatography, Chemistry, Dosage form, Methanol, Solvent, Pharmacology