2010•Journal of Thrombosis and HaemostasisOpen access

The paradoxical stimulation by a reversible thrombin inhibitor of thrombin generation in plasma measured with thrombinography is caused by α2‐macroglobulin‐thrombin

Rob J. Wagenvoord, Johanna Deinum, Margareta Elg, H.C. Hemker

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Key concepts: Thrombin, Thrombin generation, Stimulation, Antithrombins, Macroglobulin, Internal medicine, Medicine, Discovery and development of direct thrombin inhibitors

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