1992•Inflammation and drug therapy seriesRequires access

Therapeutic potential of 5-lipoxygenase inhibitors: the discovery and development of MK-886, a novel-mechanism leukotriene inhibitor

John W. Gillard, Richard A. F. Dixon, Diane Ethier, Jilly F. Evans, A. W. Ford‐Hutchinson, Réjean Fortin, Yves Girard, Yvan Guindon, Pierre Hamel, Tom R. Jones, Claire Leveillé, A. Lord, Douglas K. Miller, Howard E. Morton, Carol A. Rouzer, Christiane Yoakim

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Key concepts: Zileuton, Arachidonate 5-lipoxygenase, Leukotriene, Bronchoconstriction, Proinflammatory cytokine, Asthma, Pharmacology, Tolerability