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2011•Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia)Open access

Chemical constituents of Artocarpus kemando (Moraceae).

Gwendoline Cheng Lian Ee, Joseph Choon Fah Bong, Mawardi Rahmani, Siow Hwa Teo, Che Kiong Lim

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Abstract

The stem bark of Artocarpus kemando furnished 24-methylenecycloartenyl acetate (fatty acyl ester) (1) together with cycloartobiloxanthone (2). Compound 1 was obtained for the first time from this species. Structures of both compounds were determined using NMR and MS analysis. A cytotoxic study showed that the crude extract of the stem bark of Artocarpus kemando was significantly active against the HL-60 (human promyelocytic leukemia cell) and IMR-32 (human neuroblastoma cell) cell lines. This is the first report on the cyctotoxic activity of Artocarpus kemando. Dynamic Metadata(s).

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The stem bark of Artocarpus kemando furnished 24-methylenecycloartenyl acetate (fatty acyl ester) (1) together with cycloartobiloxanthone (2). Compound 1 was obtained for the first time from this species. Structures of both compounds were determined using NMR and MS analysis. A cytotoxic study showed that the crude extract of the stem bark of Artocarpus kemando was significantly active against the HL-60 (human promyelocytic leukemia cell) and IMR-32 (human neuroblastoma cell) cell lines. This is the first report on the cyctotoxic activity of Artocarpus kemando. Dynamic Metadata(s).

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Available abstract

The stem bark of Artocarpus kemando furnished 24-methylenecycloartenyl acetate (fatty acyl ester) (1) together with cycloartobiloxanthone (2). Compound 1 was obtained for the first time from this species. Structures of both compounds were determined using NMR and MS analysis. A cytotoxic study showed that the crude extract of the stem bark of Artocarpus kemando was significantly active against the HL-60 (human promyelocytic leukemia cell) and IMR-32 (human neuroblastoma cell) cell lines. This is the first report on the cyctotoxic activity of Artocarpus kemando. Dynamic Metadata(s).

Key concepts: Moraceae, Artocarpus, Chemistry, Cytotoxicity, Bark (sound), Traditional medicine, Botany, Stereochemistry

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