2012•TumoriRequires access
Acute myeloid leukemia carrying t(7;21)(p21;q22) — a new variant form of t(8;21) (p21;q22)
Zuomiao Xiao, WU Ya-fang, Jun Zhang, Juan Shen, Yong Wang, Bai Shu-xiao, Yanlei Gong, Yongquan Xue, Jinlan Pan
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Abstract
Objective: To investigate the clinical and laboratory characteristics of one patient with AML (acute myeloid leukemia) carrying t(7;21)(p21;q22) — a new variant form of t(8;21) (p21;q22).Methods: Cytogenetic examination was performed after culture of cells from bone marrow for 24 h. R-banding technique was used for karyotype analysis. AML1/ETO fusion gene was detected by dual-color fluorescence in situ hybridization (FISH) using AML1/ETO dual-color probes. Quantitative analysis of AML1/ETO chimeric transcripts was performed by using a real-time fluorescence-based quantitative PCR.Results: Chromosome analysis revealed a karyotype of 46, XX, t(7;21)(p21;q22),and AML1/ETO fusion gene was found in 86% of the bone marrow cells. The AML1/ETO fusion transcript copy number was 51 440/10 000 Abl copies.Conclusion: The AML patient carrying t(7;21)(p21;q22) which is a new variant form of t(8;21)(q22;q22) may have a better prognosis. DOI:10.3781/j.issn.1000-7431.2012.10.013