ScholarLens Back to search
2003•中国临床康复Requires access

The effect of calcium—antagonist on Bcl—2 and Bax mRNA expression fol—lowing ischemic brain injury

周瑞祥, 刘昌勤

Open publisher page 0 citations

Abstract

AIM:In order to explore whether the member of Bcl-2 gene family,for exam-ple,Bcl-2 and Bax,are induced after cerebral ischemia,and whether expression of genes can be modulated by calcium-antagonist.METHODS:The rat cere-bral ischemic models were made by Nagassawa and Zea Longa improvement method,by occluding left middle cerebral artery;the expression of Bcl-2 and Bax mRNA were measured by RT-PCR method.RESULTS:After administra-tion of nimodipine,Bcl-2 mRNA was up-regulated in the hippocampus at 6 and 24 h after ischemia,while Bax mRNA was down-regulated at 6 and 24h after ischemia.CONCLUSION:Calcium-antagonist can up-regulate Bcl-2mRNA and down-regulate Bax mRNA .Increasing the ratio of Bcl-2 and Bax mRNA may contribute to the anti-apoptic effect of nimodipine.

About this research paper

What this paper is about

AIM:In order to explore whether the member of Bcl-2 gene family,for exam-ple,Bcl-2 and Bax,are induced after cerebral ischemia,and whether expression of genes can be modulated by calcium-antagonist.METHODS:The rat cere-bral ischemic models were made by Nagassawa and Zea Longa improvement method,by occluding left middle cerebral artery;the expression of Bcl-2 and Bax mRNA were measured by RT-PCR method.RESULTS:After administra-tion of nimodipine,Bcl-2 mRNA was up-regulated in the hippocampus at 6 and 24 h after ischemia,while Bax mRNA was down-regulated at 6 and 24h after ischemia.CONCLUSION:Calcium-antagonist can up-regulate Bcl-2mRNA and down-regulate Bax mRNA .Increasing the ratio of Bcl-2 and Bax mRNA may contribute to the anti-apoptic effect of nimodipine.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

AIM:In order to explore whether the member of Bcl-2 gene family,for exam-ple,Bcl-2 and Bax,are induced after cerebral ischemia,and whether expression of genes can be modulated by calcium-antagonist.METHODS:The rat cere-bral ischemic models were made by Nagassawa and Zea Longa improvement method,by occluding left middle cerebral artery;the expression of Bcl-2 and Bax mRNA were measured by RT-PCR method.RESULTS:After administra-tion of nimodipine,Bcl-2 mRNA was up-regulated in the hippocampus at 6 and 24 h after ischemia,while Bax mRNA was down-regulated at 6 and 24h after ischemia.CONCLUSION:Calcium-antagonist can up-regulate Bcl-2mRNA and down-regulate Bax mRNA .Increasing the ratio of Bcl-2 and Bax mRNA may contribute to the anti-apoptic effect of nimodipine.

Key concepts: Nimodipine, Antagonist, Messenger RNA, Ischemia, Calcium, Hippocampus, Middle cerebral artery, Pharmacology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The effect of calcium—antagonist on Bcl—2 and Bax mRNA expression fol—lowing ischemic brain injury — Research Paper | ScholarLens