2002•PubMedRequires access

Changes of serum MDA and SOD levels in ischemia-reperfusion injuries of the limbs in rats preconditioned with heat stress.

Yongjian Sun, Qian Wang, Guoxian Pei, Lei Zheng, Xiong-Jin Tan

Abstract

OBJECTIVE: To study the effect of pretreatment with heat stress on ischemia-reperfusion injuries of the limbs in rats. METHODS: Rat models of ischemia-reperfusion injury were established with or without prior heat stress treatment, in which serum malondialdehyde (MDA) level and superoxide dismutase (SOD) activities were measured by means of thiobarbituric acid and nitroblue tetrazolium respectively. RESULTS: Comparison between ischemia-reperfusion group and the control group revealed significantly elevated MDA levels (P<0.01) and depressed SOD activities (P<0.01) in the condition of ischemia-reperfusion injury. Pretreatment with heat stress, however, significantly lowered the elevated MDA levels (P<0.01) and enhanced SOD activities (P<0.01) during ischemia-reperfusion injury. CONCLUSION: Pretreatment with heat stress can enhance the activity of SOD to remove free oxygen radicals in the cells.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 3 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Malondialdehyde, Thiobarbituric acid, Superoxide dismutase, Ischemia, Oxidative stress, Reperfusion injury, Medicine, Heat stress