2010•CirculationRequires access

Abstract 16750: Phosphodiesterase 4B in the L-Type Calcium Channel Complex Regulates Cardiac Calcium Current and Protects Against Ventricular Arrhythmias

Jérôme Leroy, Delphine Mika, Wito Richter, Liliana R. V. Castro, Aniella Abi‐Gerges, Moses Xie, Colleen Scheitrum, Florence Lefebvre, Julia Schittl, William A. Catterall, Flavien Charpentier, Marco Conti, Rodolphe Fischmeister, Grégoire Vandecasteele

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Abstract

Beta-adrenergic receptors (β-AR) enhance cardiac contractility by increasing cAMP levels and activating PKA. PKA increases Ca2+-induced Ca2+ release (CICR) by phosphorylating L-type Ca2+ channels (...

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Key concepts: Medicine, Calcium, Calcium channel, L-type calcium channel, Cardiology, Internal medicine, Phosphodiesterase, Nuclear magnetic resonance