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2011•CirculationRequires access

Abstract 13760: A Caveolin Targeted L-type Ca2+ Channel Antagonist Inhibits Hypertrophic Signaling Without Reducing Contractility of Cardiac Myocytes

Catherine A. Makarewich, Robert N. Correll, Hui Gao, Hongyu Zhang, Remus M. Berretta, Baohua Yang, Victor Rizzo, Jeffery D. Molkentin, Steven R. Houser

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Abstract

The Ca2+ that activates pathological hypertrophy is not thought to be the same Ca2+ that activates contraction. We hypothesize that Ca2+ influx through a subpopulation of L-type Ca2+ channels (CaV1...

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The Ca2+ that activates pathological hypertrophy is not thought to be the same Ca2+ that activates contraction. We hypothesize that Ca2+ influx through a subpopulation of L-type Ca2+ channels (CaV1...

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Available abstract

The Ca2+ that activates pathological hypertrophy is not thought to be the same Ca2+ that activates contraction. We hypothesize that Ca2+ influx through a subpopulation of L-type Ca2+ channels (CaV1...

Key concepts: Medicine, Contractility, Myocyte, Antagonist, Caveolin 3, Internal medicine, Cell biology, Endocrinology

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Abstract 13760: A Caveolin Targeted L-type Ca2+ Channel Antagonist Inhibits Hypertrophic Signaling Without Reducing Contractility of Cardiac Myocytes — Research Paper | ScholarLens